Combination Therapy in Antihypertensive Treatment

One of the most prevalent and important disease worldwide is arterial hypertension with prevalence of 35-40%. When we look worldwide prevalence of hypertension in 2000, we can see that approximately 972 millions of people were with hypertension, and the estimation is that around 1560 millions of people in 2025 will have hypertension [1]. There is a linear association between increased blood pressure and risk of cardiovascular events. High blood pressure is a strong, major risk factor for coronary artery disease, heart failure, stroke, renal disease, as well as peripheral arterial disease and it is a significant contributor to global mortality. Benefits of lowering blood pressure by approximately 12/4-5 mm Hg (SBP/DBP) will reduce stroke incidence by 35– 40%, myocardial infarction by 20–25%, and heart failure by 50% or even small reductions in blood pressure can reduce risk of cardiovascular mortality. Only 2 mm Hg decrease in mean office systolic blood pressure reduces stroke and ischemic heart disease mortality risk by 10% and 7%, respectively.